COVID19

Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations: The role of G-quadruplexes, exosomes and microRNAs

January, 2022

Highlights

• mRNA vaccines promote sustained synthesis of the SARS-CoV-2 spike protein.

• The spike protein is neurotoxic, and it impairs DNA repair mechanisms.

• Suppression of type I interferon responses results in impaired innate immunity.

• The mRNA vaccines potentially cause increased risk to infectious diseases and cancer.

• Codon optimization results in G-rich mRNA that has unpredictable complex effects.

Abstract

Immune imprinting, breadth of variant recognition and germinal center response in human SARS-CoV-2 infection and vaccination

January, 2022

Highlights

• Vaccination confers broader IgG binding of variant RBDs than SARS-CoV-2 infection

• Imprinting from initial antigen exposures alters IgG responses to viral variants

• Histology of mRNA vaccinee lymph nodes shows abundant germinal centers

• Vaccine spike antigen and mRNA persist for weeks in lymph node germinal centers

Abstract

Performance of the SARS-CoV-2 RT-PCR test as a tool for detecting SARS-CoV-2 infection in the population

DSA ADS Course - 2022

Performance of the SARS-CoV-2 RT-PCR test as a tool for detecting SARS-CoV-2 infection in the population

COVID19, Public Policy, Health Policy, SARS-CoV-2, RT-PCR Test, Infectious Potential, Laboratory Quality Assurance, Dr. Kary Mullis, Cycle Threshold Values

Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial

April, 2022

Background

Associations between vitamin D (VD) deficiency and the risk of SARS-CoV-2 infection have been documented in cross-sectional population studies. Intervention studies in patients with moderate to severe COVID-19 have failed to consistently document a beneficial effect.

Objective

To determine the efficacy and safety of VD-supplementation in the prevention of SARS-CoV-2 infection in highly exposed individuals.

Methods

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