Inverse Probability of Treatment Weighting

Planning a method for covariate adjustment in individually randomised trials: a practical guide

April, 2022

Abstract

Background

It has long been advised to account for baseline covariates in the analysis of confirmatory randomised trials, with the main statistical justifications being that this increases power and, when a randomisation scheme balanced covariates, permits a valid estimate of experimental error. There are various methods available to account for covariates but it is not clear how to choose among them.

Methods