Stem Cells

Post-Gastrulation Synthetic Embryos Generated Ex Utero from Mouse Naïve ESCs

August, 2022

Highlights

  • Advanced synthetic embryos (sEmbryos) self-assembled from ESCs in an ex utero setup
  • Naïve ESCs give rise to all embryonic and extra-embryonic compartments in sEmbryos
  • Post-gastrulation stem cell derived sEmbryos develop organ specific progenitors
  • Extra-embryonic compartments adequately develop in post-gastrulation whole sEmbryos

Summary